Observations on the absorption of iron from foods tagged with radioiron. Is a 40 % absorption of iron from a ferrous ascorbate reference dose appropriate to assess iron absorption independent of iron status. Ferrous ascorbate is contraindicated in patients with. Those who are iron deficient may absorb up to 95% of an iron dose. May 02, 2012 after its absorption, iron levels in the blood reach a maximum after about 7 hours and remain elevated for 24 hours. As is evident from table 2, the lowest absorption efficiencies were 4. Blood plasma measurements were obtained over the first 6 hours of absorption.
Milk inhibits and ascorbic acid favors ferrous bisglycine. Ferrous sulfate therefore better patient compliance. For example, a single ferrous sulfate 325mg tablet contains 60mg of elemental iron, so thrice daily dosing provides 180mg of elemental iron per day, well within the recommended daily range of 150200mg for irondeficient patients. However, we dont know if vitamin c really increases the absorption of iron from ferrous fumarate.
Pdf bioavailability of iron bisglycinate chelate in water. Ferrous ascorbate is the worlds most widely recognized reference iro many individuals, so iron supplementation is essential to control iron deficiency anaemia. Actiferon slow release iron tablets are easy to swallow and easy on stomach. Dm pharma ferrous ascorbate folic acid, zinc sulphate. Comparison study of oral iron preparations using a human. Two levels of fe fortification were studied in two groups of subjects. Jun 21, 20 ferrous sulphate feso 4, along with the ferrous salts, ferrous fumarate and ferrous gluconate, are the most common form of iron supplements currently in use. Ascorbic acid reduces ferric iron to ferrous iron which remains soluble even at neutral ph. Iron is recycled by the body and produce erythroid precursor cells. Biochemistry, iron absorption statpearls ncbi bookshelf.
Absorption of ferrous ascorbate averaged 52% higher than ferrous sulphate in subjects with id. Experiments suggest that adding 50 to 85 grams of meat to a meal results in a 1. Suboneyo expertise in customized high quality, costeffective organic minerals which are used in many neutraceutical, food applications. The present study was planned to compare the efficacy and side effects of ferrous sulphate, ferrous fumarate, ferrous ascorbate, sodium feredetate and ferrous bisglycinate in treatment of iron deficiency anemia in pregnancy. Ferrous versus ferric oral iron formulations for the. Its biologically active form, vitamin c, functions as a reducing agent and coenzyme in several metabolic pathways. However, an excess of 200 mg of vitamin c per 30 mg of elemental iron is required to enhance the absorption of highly available iron salts, such as ferrous sulfate. Ckd receiving iron sucrose, oral ferrous ascorbate and ferrous sulfate. Absorption of iron from both compounds was inversely.
Structural basis for promotion of duodenal iron absorption by. Effect of vitamin c on iron absorption full text view. The estimated absorption rate of the ferrous salts is. The greater absorption of ironin vivo from ferrous ascorbate fehl 2 as compared with ferrous sulfate has been ascribed both to retardation or prevention of feii oxidation by ascorbate and to the existence of feii as a chelate with ascorbate. Ferric irons and heavily chelated iron should not be used as they are poorly and. There was a direct correlation between the absorptions of log ferrous ascorbate and log iron bisglycine chelate given with water r 0. Proferrin es and proferrin forte can be used when regular iron supplements such as ferrous sulfate or ferrous fumarate are not tolerated or absorbed. Molar mass of ferrous ascorbate is 408 gmol atomic mass of fe is 55.
The results suggest that an absorption of about 40 % of a 3 mg reference dose of ferrous iron is given in a fasting state, roughly corresponds to the absorption in borderlineirondeficient subjects. Significant levels of ntbi were detected even at lower doses, e. The amount of fe absorbed from reference doses of ferrous ascorbate was measured. When given in water, iron absorption from the bisglycinate was 31% compared with 72% from the ascorbate. Iron availability is not only related to the particular food source but also to the interaction with other foods and with gastrointestinal secretions. Enhancers of iron absorption are dominated by the effect of ascorbic acid. Folic acid is vital for the biosynthesis of purines and thymidylate of nucleic acids.
Addition of ascorbic acid converts the ferric form to ferrous form thus making it absorbable from duodenum and upper jejunum, resulting in considerable enhancement of the absorption of iron. It is found naturally in citrus fruits and many vegetables. The product resulting by reacting ascorbic acid and iron. Evaluation of efficacy, safety and cost of oral and parenteral iron.
Plasma vitamin c was measured by the method of butts and mulvihill 11, adapted for the cobas mira analyser f. These data support the effective downregulation of iron absorption from all 3 sources of iron as iron reserves increase. Ironascorbate ferrousascorbate is used as a reagent in cell culture and other systems to evaluate various aspects of oxidative stress and antioxidation. Ferrous sulfate is the least expensive and most commonly used oral iron supplement. Take this medication by mouth, usually once daily or as directed by your doctor this medication is best taken on an empty stomach 1 hour before or. Subjects with normal iron stores absorb 10% to 35% of an iron dose. Simultaneous consumption of 25100 mg of vitamin c has been shown to increase the absorption of nonheme iron by fourfold. The primary purpose of this study is to demonstrate the efficacy and tolerability profile of ferrous bisglycinate chelate to support the registration of this product as a drug in india. Bioavailability and the mechanisms of intestinal absorption of iron from ferrous ascorbate and ferric polymaltose in experimental animals. M, close to the detection limit of the assay that was used 34.
In children, it is used as an effective oral iron supplement to treat iron deficiency anemia. The goal of therapy for iron deficiency is both correction of the hemoglobin level and replenishment of body iron stores. Find here online price details of companies selling ferrous ascorbate tablets. Ferrous ascorbate is contraindicated in patients with haemolytic anemia, hemochromatosis, hemosiderosis and other iron overload disorders. Ferrous ascorbate an overview sciencedirect topics. A clinical study was conducted comparing the ferrous ascorbate formulation with that of ferrous sulphate in 18 healthy volunteers. Ferrous sulfate is the least expensive and most commonly used oral. Ferric irons and heavily chelated iron should not be used as they are poorly and inefficiently absorbed. Intestinal mucosal cells in the duodenum and upper jejunum absorb the iron. Hematinic may aggravate regional enteritis, peptic ulcer and ulcerative colitis. Slow relese iron therapy for better absorption and. Ferrous ascorbate has less gastrointestinal side effects and is readily absorbed than. For nearly 4 decades, studies on iron preparations have been benchmarked against ferrous ascorbate. Comparison of various oral iron salts in the treatment of.
Advantages of ferrous ascorbate on other forms of iron. Ascorbic acid, vitamin c, increases the absorption of nonheme sources of iron. In the human body, iron exists mainly in erythrocytes as the heme. There was a significant correlations between ln iron absorption of iron bisglycinate chelate with ln serum ferritin r 0. Jul 12, 2010 in india, ferrous ascorbate, 1 tablet daily is a widely accepted form of treatment for iron deficiency anaemia. Anelli reported that ferrous salts form a colored complex with ascorbic acid. The method was found to be linear in the range of 1080. This has fantastic absorption as ascorbic acid enhances absorption of iron. Exogenous administration of folic acid is essential for normal erythropoiesis process. The technique depends on reduction of ferric to ferrous ions by ascorbate, which is. The visible spectrophotometry technique needs reduction of ferric ion to the ferrous form in order to use chromogenic methods that have larger analytical sensitivity than those specific for ferric iron. The efficiency of absorption depends on the salt form, the amount administered, the dosing regimen and the size of iron stores. Ferrous ascorbate drug information drugsupdate india.
The most commonly prescribed preparation, the ferrous and ferric salts, include ferrous sulfate, ferrous gluconate, ferrous ascorbate, ferrous fumarate, ferric carboxymaltose etc. Comparison between ferrous ascorbate and colloidal iron in. Ferrous ascorbate is a synthetic form of iron and vitamin c. Get info of suppliers, manufacturers, exporters, traders of ferrous ascorbate tablets for buying in india. How much ferrous ascorbate equivalent to elemental iron. In the same study, it was reported that ironiiipolymaltose at a dose of 150 mg iron resulted in a maximal ntbi concentration of only 0. In the united kingdom uk, ferrous sulphate tablets 200 mg, usually containing 65 mg of elemental iron, are most often the first choice for treatment of iron deficiency anaemia. One study reported that adding just 63 mg of vitamin c to a meal rich in nonheme iron yielded a 2. Stable isotopelabelled vitamin c as a probe for vitamin c. It has been demonstrated that feii ascorbate is less easily oxidized than feii in ferrous sulphate. Synthesis of ferrous ascorbate involved use of ferrous sulphate as precursor molecules.
At ph6 to 8, the solubility effect is enhanced by ascorbate, which is beneficial for the absorption of iron from ferrous ascorbate. The most commonly available oral preparations include ferrous sulfate, ferrous gluconate and ferrous fumarate. A study to demonstrate the efficacy and tolerability of. The accuracy of the proposed methods was evaluated by. The available literature and our own results demonstrate that fehl 2 dissociates in aqueous solution into a monomeric cationic species. Vitamin b12 and zinc in actiferon in delayed release form avoiding the inhibition. Properties of ferrous ascorbate are thus considered the gold standard in iron therapy. This study will measure the iron absorption in children from a meal containing some ferrous fumarate with and without vitamin c.
Valenzuela c1, olivares m, brito a, hamiltonwest c, pizarro f. Complex stability of ferrous ascorbate in aqueous solution. All three forms are well absorbed but differ in elemental iron content. Ajpa development and validation of analytical methods for. The usual adult dose can be administered see section 4. Iron absorption from ferrous bisglycinate and ferric. Aug 27, 20 although a 40 % absorption of a standard reference dose corresponds to iron fe absorption in borderline fedeficient subjects, this percentage is currently applied to all subjects independent of fe status. Advantages and limitations of iron amino acid chelates as. Pharmacoeconomic evaluation of ferrous ascorbate, ferrous. Comparison of efficacy of ferrous calcium citrate vs ferrous. Ferrous ascorbate, ferrous ascorbate in pregnancy drug information drugs update india, ferrous ascorbate and lactation drug information drugs update india, ferrous ascorbate and children drug information drugs update india,pharmacokinetics of ferrous ascorbate,pharmacodynamics of ferrous ascorbate,clinical efficacy of ferrous ascorbate,adverse reactions of ferrous ascorbate,precautions of.
Mar 26, 2015 the low absorption rate results in lessthanideal dosing of three pills per day in order to reverse irondeficiency. The study involved characterization of solid state form of ferrous ascorbate. Pdf although a 40 % absorption of a standard reference dose corresponds to iron fe absorption in borderline fedeficient subjects, this. Ferrous versus ferric oral iron formulations for the treatment of iron. Pdf is a 40 % absorption of iron from a ferrous ascorbate. Ascorbic acid is an essential nutrient in human diets, and necessary to maintain connective tissue and bone. Is a 40 % absorption of iron from a ferrous ascorbate. Dec 11, 2007 vitamin c can improve the amount of iron that the body absorbs, therefore it is often added to foods too.
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